Homodimerization of APOBEC3G is required for inhibition of Alu retrotransposition
نویسندگان
چکیده
منابع مشابه
APOBEC3G Oligomerization Is Associated with the Inhibition of Both Alu and LINE-1 Retrotransposition
Alu and LINE-1 (L1), which constitute ~11% and ~17% of the human genome, respectively, are transposable non-LTR retroelements. They transpose not only in germ cells but also in somatic cells, occasionally causing cancer. We have previously demonstrated that antiretroviral restriction factors, human APOBEC3 (hA3) proteins (A-H), differentially inhibit L1 retrotransposition. In this present study...
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Mobile elements such as Alu repeats have substantially altered the architecture of the human genome, and de novo mobile element insertions sometimes cause genetic disorders. Previous estimates for the retrotransposition rate (RR) of Alu elements in humans of one new insertion every approximately 100-125 births were developed prior to the sequencing of the human and chimpanzee genomes. Here, we ...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2011
ISSN: 1742-4690
DOI: 10.1186/1742-4690-8-s2-p67